DNA methylation and histone modification promote changes in chromatin structure that may affect gene expression in a heritable manner without directly altering the genome. As such, these phenomena are considered to be epigenetic in nature and are believed to contribute to the normal processes of human development but also to aberrant disease states such as cancer. Epigenetic processes probably contribute mechanistically to toxicant-induced changes in gene expression and cancer. Nickel is a potent human carcinogen that has been shown to alter DNA methylation patterns and affect histone acetylation status. Both of these changes are associated with the proximity of the affected regions to heterochromatin. The two processes probably occur in concert in mammalian cells. However, in yeast cells, DNA methylation is absent, and nickel is capable of regulating gene expression through changes in acetylation of the lysine residues in the N terminal tail of histone H4. Arsenic is another important environmental carcinogen, and it is methylated during its metabolism. Hence, it has been proposed that arsenic metabolism may deplete intracellular methyl group stores and thereby lead to changes in DNA methylation that may be involved in carcinogenesis. However, the data concerning DNA methylation changes following arsenic exposure are equivocal, leading researchers to propose that DNA hypo- and hypermethylation are both important in the development of arsenic-induced cancers. Heightened awareness by toxicologists of the importance of epigenetics in normal human development and in carcinogenesis should lead to the identification of other toxicants that manifest their effects, at least in part, via epigenetic mechanisms.

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If I'm in a dgaf mood, half n half. Alternatively, get a good whole milk chocolate milk and warm it up. Shoutout to Monument Farms Chocolate Milk in Vermont. Hotdamn.

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something to think about over the weekend... why AXP, BAC, WFC, XLF and more financials make all time highs today?

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I think people don’t understand that QE starts today and grows from here. N rate cuts next year. New voting members picked by Trump . Pure money printer goes brrrrr 2026 setup. I mean inflation will go up but who cares.

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Is this the V? Looks to me like a reverse N

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NFLX n gainz tonight

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Market don’t let me use the N word

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Think the count of N words was about 69

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I don't think I've heard the n word so many times in a span of one earnings call

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Holy shit AVGO down 11%????? Youd think they said the n word or something

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