“Dead cat bounce” “Everything overextended” “Last gasp of liquidity” “this is nonsense” “It’s all forced buying” “Pure hopium rally” “This won’t age well” “You’ll see soon”
More pure unadulterated bear cope. Sorry should have tagged NSFW
Fine:
1. Development of the therapy used a market-irrelevant trial population. Most notably, exclusion criteria for TILVANCE-301 was patients with >1 prior therapy in any setting. This patient population does not exist in the real-world as it's typically line 4-5 by the time you'd consider this therapy. Vem, Pembro/Nivo/Ipi, CTX are always going to come first and insurance is rarely going to cover this given specific performance criteria and exclusion criteria
2. Key limitation is related to point 1. Patients that have received prior chemotherapy have notably poor TILs, as with vemurafenib.
3. No one is going to pick this over Vem/Nivo+Ipi.
4. Profit margins for TIL are so low that even if they had sales, they would likely make a loss. See Dendreon.
5. This is largely a market that is/will be covered by the IRA, and there is considerable market pressure on pricing. Autologous therapies are on their way out because of pricing and manufacturing pressure